What factors determine the success of reproductive immune therapy?

The factors that determine the success of immunotherapy. Number one, selecting the right patient. So you can't give it to every patient who will have ... any patient who has recurrent miscarriage or implantation failure. You have to have a set of tests to look for the pathology or the problem. So that's number one. Number two, you have to have the treatment that will deal with that abnormal physiology or that pathology. So you have to specify the treatment to target the immune issue. Number three, it's important when you start the treatment. There are a couple of reviews by David Clark and Caroline Coulam who showed that if you give the treatment like IVIG in their studies before ovulation or before pregnancy, the results are significantly better. But if you give them ... Or IVIG drips. After pregnancy already, the result is not good. Again, Caroline Coulam showed in her review that if you give the immune treatment in the form of IVIG to all patients with recurrent miscarriage or implantation failure, you can't see the result because it's diluted for many reasons, because this patient miscarried for many reasons. It's basically a very heterogenic group. But if you give the IVIG to patients who have an abnormal immune balance based on immune testing, three out of four studies showed positive outcome and improvement in the live birthrate.